The French National Research Institute for Agriculture, Food, and the Environment (INRAE) is a public research establishment. It is a community of 12,000 people with more than 200 research units and 42 experimental units located throughout France. The institute is among the world leaders in agricultural and food sciences, in plant and animal sciences, and is 11th in the world in ecology and environment. INRAE’s main goal is to be a key player in the transitions necessary to address major global challenges. In the face of the increase in population, climate change, scarcity of resources and decline in biodiversity, the institute develops solutions for multiperformance agriculture, high quality food and sustainable management of resources and ecosystems.
Work environment, missions and activities
The MICALIS Institute offers a dynamic and stimulating scientific environment (20 teams, 330 persons, multiple nationalities). It provides state-of-the-art facilities, with a collaborative and lively atmosphere. The INRAE research campus hosts a vibrant and diverse research community focusing notably on basic research, biomedicine, evolution and ecology. It is well connected to other major research areas. Jouy en Josas is located a few kilometers from Paris.
The applicant will take part in the ERC-funded project “Homo.symbiosus” granted to Joël Doré, and be hosted in the FInE team (Functionality of the Intestinal Ecosystem) of the Micalis Institute (INRAE, Jouy en Josas).
The microbiomics revolution has favoured the recognition of the gut as a true organ and the importance of man-microbes symbiosis in health and disease. Derived from a long co-evolution, the latter is now challenged by numerous environmental changes that are introduced with a modern lifestyle: nutritional transition and changes in birth modalities and therapeutic practices. As a consequence, a large fraction of the human population has tentatively entered an alternative stable state: a state of altered man-microbes symbiosis. This transition could explain the exponential increase of immune-mediated diseases that affect one third of the human population today and are notoriously difficult to cure using current therapeutic approaches. In this context, the postdoctoral applicant will undertake research to validate the concept of transition to an alternative stable state while assessing the potential of diet to promote such a transition. He/she will model the transition to identify tipping points and derive predictors of transition, assembling insights and contributions from theoretical and experimental ecology, quantitative and functional microbiomics, and preclinical work.
Training and skills
The applicant should have a recent PhD with a strong knowledge in gut molecular microbial ecology. Skills in bioinformatics (Unix/Linux operating system, programming language) and biostatistics (R programming and statistical programming language) dedicated to handle 16S sequencing data and meta-Omics data are mandatory. Bench skills in molecular biology such as DNA/RNA extraction, PCR/qPCR and Elisa assays will be a plus. The project will be a tight collaboration with Beatrice Laroche’s group at MIAGE – Dynenvie (INRAE, Jouy en Josas) to connect microbiomics data with mathematical modelling.
INRAE's life quality
By joining our teams, you benefit from:
- 30 days of annual leave + 15 days "Reduction of Working Time" (for a full time);
- parenting support: CESU childcare, leisure services;
- skills development systems: training, career advise;
- social support: advice and listening, social assistance and loans;
- holiday and leisure services: holiday vouchers, accommodation at preferential rates;
- sports and cultural activities;
- collective catering.