Postdoctoral position OT-28769
Bidirectional crosstalk between stress response and lipid metabolism in rainbow trout under thermal and hypoxic stress : A nutritional approach.
64310 SAINT PEE SUR NIVELLE
INRAE presentation
The French National Research Institute for Agriculture, Food, and Environment (INRAE) is a major player in research and innovation. It is a community of 12,000 people with 272 research, experimental research, and support units located in 18 regional centres throughout France. Internationally, INRAE is among the top research organisations in the agricultural and food sciences, plant and animal sciences, as well as in ecology and environmental science. It is the world’s leading research organisation specialising in agriculture, food and the environment. INRAE’s goal is to be a key player in the transitions necessary to address major global challenges. Faced with a growing world population, climate change, resource scarcity, and declining biodiversity, the Institute has a major role to play in building solutions and supporting the necessary acceleration of agricultural, food and environmental transitions.
Work environment, missions and activities
WORKING ENVIRONMENT :
Nutrition Metabolism Aquaculture (NuMéA) INRAE-UPPA research unit is known worldwide and stands as a leading French research structure devoted to all aspects of fish nutrition and metabolism, including protein, lipid and carbohydrate metabolism, energetics, and environmental impact. Research at NuMéA is driven by the challenges posed by limited marine resources, the global expansion of aquaculture, and the ongoing effects of climate change. The unit focuses on understanding the cellular and molecular mechanisms, particularly nutrient-driven processes, that regulate key metabolic functions and growth in fish. Ultimately, the goal is to provide innovative aquaculture strategies that ensure the production of healthy, nutritious food for the global population while promoting sustainability and animal welfare.
SCIENTIFIC CONTEXT :
Global aquaculture heavily depends on the environment, which makes it inherently vulnerable to the effects of climate change. Two important abiotic factors threatened by climate change are temperature and dissolved oxygen concentration. These two factors are closely linked, as water temperatures rise, dissolved oxygen levels decrease due to their inverse relationship.
In open or large-scale aquaculture systems, direct control of water temperature is often not feasible. Therefore, alternative strategies are urgently needed to improve fish resilience during extreme temperature and hypoxia events. Among these, nutritional interventions represent a promising approach, with the potential to meet increasing energetic and nutritional demands associated with mitigating the effects of these abiotic climate change stressors.
OBJECTIVES :
The postdoctoral researcher will investigate the cellular stress response of the rainbow trout under thermal and hypoxic stress, with specific interest in the identification of regulatory interactionsbetween stress response and lipid metabolism in the digestive system. The postdoctoral researcher will also investigate the effects of nutritional interventions on the stress response.
She/He will be responsible for :
-The integration of omics data to Identify :
- Stress response mechanisms under thermal and hypoxic stress.
- Regulatory interactions between stress response and lipid metabolism.
-Investigate the effects of nutritional interventions on the stress response.
-Investigate stress-induced differential expression of microRNAs involved in lipid metabolism.
Training and skills
The position requires a PhD degree less than 3 years old (or equivalent) in Molecular Biology, Metabolism, Stress Response, Animal Nutrition or related overlapping fields.
- Desired knowledge : Solid foundation in molecular and cellular biology and in R programming for statistical analysis and data visualization.
- Experience appreciated : In nutrition and metabolism, as well as transcriptomics and multi- omics data analysis. Experience in aquaculture and/or microRNA research is a plus.
- Required skills : Excellent written and verbal communication skills in English, autonomy, initiative, and ability to work in a collaborative environment.
INRAE's life quality
By joining our teams, you benefit from (depending on the type of contract and its duration):
- up to 30 days of annual leave + 15 days "Reduction of Working Time" (for a full time);
- parenting support: CESU childcare, leisure services;
- skills development systems: training, career advise;
- social support: advice and listening, social assistance and loans;
- holiday and leisure services: holiday vouchers, accommodation at preferential rates;
- sports and cultural activities;
- collective catering.
How to apply
For apply send the listed documents :
- Cover letter detailing research experience and interest
- Curriculum vitae (CV)
- Contact information for two references
All persons employed by or hosted at INRAE, a public research establishment, are subject to the Civil Service Code, particularly with regard to the obligation of neutrality and respect for the principle of secularism. In carrying out their functions, whether or not they are in contact with the public, they must not express their religious, philosophical or political convictions through their behaviour or by what they wear. > Find out more: fonction publique.gouv.fr website (in French)