Junior Research Scientist on virus-induced resistance

68000 COLMAR

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INRAE presentation

The French National Research Institute for Agriculture, Food, and the Environment (INRAE) is a public research establishment under the dual authority of the Ministry of Agriculture and the Ministry of Research.

INRAE is recruiting researchers by open competition and offering permanent position.

It is a major player in research and innovation created on 1st of January 2020. INRAE is a research institute resulting from the merger of INRA and IRSTEA. It is a community of 12,000 people with more than 200 research units and 42 experimental units located throughout France.

The institute is among the world leaders in agricultural and food sciences, in plant and animal sciences, and is 11th in the world in ecology and environment. INRAE’s main goal is to be a key player in the transitions necessary to address major global challenges. In the face of the increase in population, climate change, scarcity of resources and decline in biodiversity, the institute develops solutions for multiperformance agriculture, high quality food and sustainable management of resources and ecosystems.

Work environment, missions and activities

The Grapevine Health and Wine Quality joint research unit, recognized worldwide for its work on grapevine health, studies the biology and the pathogenicity of grapevine viruses, their vector transmission, their diversity, and develops detection methods together with anti-viral and anti-vector strategies. The unit has modern and efficient infrastructures and facilities (experimental plots, containment laboratories and greenhouses, phenotyping, imaging and metabolomics platforms, computer server).
You will join the Virology and Transmission team (21 people), which has skills in molecular and cellular biology, plant virology, nematology and entomology. The aim of the project is to identify the molecular mechanisms underlying premunition, viral-induced resistance following an infection with a mild virus strain, which can block a subsequent infection by a more virulent virus. The characterization and understanding of the underlying mechanisms are essential to develop premunition as an efficient and sustainable antiviral strategy.
The research team has already obtained promising results with this approach against the grapevine fanleaf virus (GFLV). The unit has knowledge on the genomic and phenotypic variability of GFLV, on defence reactions induced by this virus on model plants and the grapevine and on the viral determinants responsible for its pathogenicity and its transmission by the nematode vector. You will design and develop your project on the characterization of the molecular mechanisms induced by GFLV and particularly on the mechanisms required for the immune antiviral response.
You will conduct your research on model herbaceous plants and on the grapevine. The research areas will include RNA interference, super-infection exclusion and virus fitness of competing isolates. By combining molecular virology, cellular biology, imaging, and omics analyses, as well as molecular and phenotypic data collected from premunition experiments already set-up in vineyards, you will investigate the interactions between the different virus strains in a multi-partite genomic composition context and will define their impact on premunition.

Training and skills

PhD or equivalent

Candidates must have a PhD or equivalent.
A PhD and post-doctoral experience in plant-virus interactions would be desirable. Training in molecular biology and virology, as well as experience in the field of virus-host interactions, plant defence and viral counter-defence mechanisms would be desirable. Skills in high-throughput sequencing and transcriptomics analyses would be a bonus.
Candidates should have a good command of English, and long-term international experience would also be desirable. Successful candidates who have not yet acquired this experience abroad will be required to do so after their probationary period (1st year).

INRAE's life quality

By joining our teams, you benefit from:

- 30 days of annual leave + 15 days "Reduction of Working Time" (for a full time);
- parenting support: CESU childcare, leisure services;
- skills development systems: training, career advise;
- social support: advice and listening, social assistance and loans;
- holiday and leisure services: holiday vouchers, accommodation at preferential rates;
sports and cultural activities;
- collective catering.

Offer reference

  • Profile number: CR-2021-SPE-1
  • Corps: CRCN
  • Category: A
  • Open competition number: 7

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