Junior Research Scientist in Mechanisms of resistance to anthelmintics and insecticides in a multi-exposure context


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INRAE presentation

The French National Research Institute for Agriculture, Food, and the Environment (INRAE) is a public research establishment under the dual authority of the Ministry of Agriculture and the Ministry of Research.

INRAE is recruiting researchers by open competition and offering permanent position.

It is a major player in research and innovation created on 1st of January 2020. INRAE is a research institute resulting from the merger of INRA and IRSTEA. It is a community of 12,000 people with more than 200 research units and 42 experimental units located throughout France.

The institute is among the world leaders in agricultural and food sciences, in plant and animal sciences, and is 11th in the world in ecology and environment. INRAE’s main goal is to be a key player in the transitions necessary to address major global challenges. In the face of the increase in population, climate change, scarcity of resources and decline in biodiversity, the institute develops solutions for multiperformance agriculture, high quality food and sustainable management of resources and ecosystems.

Work environment, missions and activities

The position opens in the INTHERES Unit created in 2018 (project 2020-25, validated by Hcéres 2019) on the ENVT (National Veterinary School of Toulouse) site, around resistance to anti-infectives, in the axis 'Resistance to Anthelmintics and Insecticides'.
In the context of pharmaco-resistance to anti-infectives, the objective of our research is to understand the molecular events of adaptation of pathogens to drug treatments. Faced with the loss of efficacy of conventional therapies in breeding, alternatives are developed (alternation or combination of several drugs, plants with anthelmintic effect, etc.)
The axis brings together interdisciplinary researchers, who study the dynamics of the development of these resistances, with the final objective of developing effective innovative strategies to fight against resistant pathogens. The recruitment profile is part of the research dynamic in this area, and the questions will take into account the new therapies implemented in breeding in response to the loss of efficacy of conventional drugs. Thus, the project will focus on the study of the molecular mechanisms underlying the therapeutic efficacy of new anthelmintic approaches, and the adaptation of pathogens in a context of multiple exposure (drug combinations; natural approaches based on rich plants in tannin ...).
Your mission will consist in setting up a research project aimed at studying the adaptation phenomena of targets to conditions of multiple exposure. For this, you will develop original models of exposure, pharmacological and molecular approaches, to study (i) the mechanisms of action of natural substances, (ii) the impact of mixtures of anthelmintic substances on the development of resistance in targets of clinical interest (eg, nematodes). You will then look for ways to target these processes to counter resistance, (iii) and propose operational strategies to livestock professionals.
You will establish links between the different projects of the unit on anti-infectious drugs, in particular, on insect models resistant to biocides. You will strengthen connections with institutional and international partners, as well as livestock and veterinary medicine professionals. You will train in the models and approaches developed in the team to set up comparative -omics approaches adapted to your questions, in the C. elegans nematode model, and in the parasites of interest.
You will establish connections with livestock and institutional professionals and strengthen international collaborations with parasitologists who will facilitate access to the expertise and biological material required for the project. You will rely on accessibility to the genomes of the main parasites of clinical interest and the technological environment offered by high-performance platforms on the Toulouse site.
Your mission will also consist of supervising students, and you will consider taking HDR.

Strenghten the link between the different projects of the unit, and with institutional and professional partners

Training and skills

PhD or equivalent

Candidates must have a PhD or equivalent.
A solid training in molecular biology and genetics is expected, with in-depth knowledge of cellular mechanisms regulating the expression of genes and proteins. A mastery of molecular tools and software adapted to these studies (genomic editing, bioinformatics software for the analysis of genomes, transcriptomes, and proteomes) is required. Notions of pharmacology, and / or parasitology will be appreciated.
The balance of these different areas of expertise will be considered on a case-by-case basis, and targeted training will be considered.
You will have to present teaching and writing skills.
You must have a good team spirit, and excellent communication skills; and dynamic to promote interactions between research partners, and develop interdisciplinary approaches in an international environment.
Fluency in English is desirable as well as long-term international experience.

INRAE's life quality

By joining our teams, you benefit from:

- 30 days of annual leave + 15 days "Reduction of Working Time" (for a full time);
- parenting support: CESU childcare, leisure services;
- skills development systems: training, career advise;
- social support: advice and listening, social assistance and loans;
- holiday and leisure services: holiday vouchers, accommodation at preferential rates;
sports and cultural activities;
- collective catering.

Offer reference

  • Profile number: CR-2021-SA-1
  • Corps: CRCN
  • Category: A
  • Open competition number: 27

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