OPEN COMPETITIONS CR-2021-ALIMH-2

Junior Research Scientist on perinatal exposome and food allergy

91191 GIF SUR YVETTE

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INRAE presentation

The French National Research Institute for Agriculture, Food, and the Environment (INRAE) is a public research establishment under the dual authority of the Ministry of Agriculture and the Ministry of Research.

INRAE is recruiting researchers by open competition and offering permanent position.

It is a major player in research and innovation created on 1st of January 2020. INRAE is a research institute resulting from the merger of INRA and IRSTEA. It is a community of 12,000 people with more than 200 research units and 42 experimental units located throughout France.

The institute is among the world leaders in agricultural and food sciences, in plant and animal sciences, and is 11th in the world in ecology and environment. INRAE’s main goal is to be a key player in the transitions necessary to address major global challenges. In the face of the increase in population, climate change, scarcity of resources and decline in biodiversity, the institute develops solutions for multiperformance agriculture, high quality food and sustainable management of resources and ecosystems.

Work environment, missions and activities

The medicine and healthcare technologies joint research unit (CEA-INRAE-Université Paris-Saclay, CEA de Saclay, Lead C. Junot) consists of 125 permanent staff spread over 3 departments, including Pharmacology and Immunoanalysis where the Food Allergy Laboratory is integrated. This team is composed of 5 scientists (1DR, 1CR, 3IR), 2 engineers (2 IE), 3 technicians (1 AI, 2 TR including an accounts and administrative manager), and is attached to the INRAE-Jouy en Josas Research Center.
Research performed within the Pharmacology and Immunoanalysis department concerns Medicine (emerging infections, allergology, neurology, hepatology) and bio-defence. It relies on the design and development of detection and diagnostic tools (genetic and immunologic tests) and "omics" approaches combining metabolomics, lipidomics, glycomics, and metaproteomics (MetaboHub network), as well as the development of cell and animal models for mechanistic studies. The methods and knowledge are applied to precision medicine (patient stratification, identification of biomarkers, personalized medicine) and analysis of cohorts.
You will join research dealing with perinatal exposome analysis and its impact on child health, notably the development of food allergies in childhood. This research combines biologists, analytical chemists, computer and statistical scientists, epidemiologists, and clinicians. They rely on the integrative analysis of biological samples (breast milk, meconium) collected within French mother-child cohorts (EDEN, ELFE): untargeted metabolomic and proteomic analysis using liquid chromatography coupled with mass spectrometry, targeted analysis of immune factors, microbiota composition analysis (in coll. with Micalis Institute, INRAE-Jouy en Josas), associated with environmental and health information collected within the cohorts.
Your mission will involve the biological interpretation of fingerprints related to exposure and predispositions to food allergies identified through these multi-omics approaches. By putting these data in a physiological context, integrating mainly barrier functions, immunity and microbiota, you will put forward mechanistic hypotheses that you will then help verify thanks to in vitro (intestinal cells, PBMC) and in vivo (integrative mother-child and food allergy mouse model) models. You will undertake the biological interpretation of data already obtained from more than 300 mother-child dyads, then of those obtained from new perinatal samples generated from new cohorts within the context of two ANR programmes (InfaDiet and CIMMAP).
You will join consortia already formed and build new ones. You will promote and communicate the results through scientific communities and to socio-economics partners.

Training and skills

PhD or equivalent

Candidates must have a PhD or equivalent.
Training in biology or life science is highly recommended.
The capacity to develop integrative projects within the field of omics in relation to Human health, as well as skills in interpreting multi-omic data, especially in the field of immunology/allergology and (intestinal) physiology (systems biology) would be highly desirable.
The ability to work in a research team with various contacts and within consortia grouping people with various skills and expertise (biologists, chemists, epidemiologists, bioinformaticians and statisticians, nutritionists, toxicologists…) would be appreciated.
Candidates should have a good command of English, and long-term international experience would also be desirable. Successful candidates who have not yet acquired this experience abroad will be required to do so after their probationary period (1st year).

INRAE's life quality

By joining our teams, you benefit from:

- 30 days of annual leave + 15 days "Reduction of Working Time" (for a full time);
- parenting support: CESU childcare, leisure services;
- skills development systems: training, career advise;
- social support: advice and listening, social assistance and loans;
- holiday and leisure services: holiday vouchers, accommodation at preferential rates;
sports and cultural activities;
- collective catering.

Offer reference

  • Profile number: CR-2021-ALIMH-2
  • Corps: CRCN
  • Category: A
  • Open competition number: 9
Centre Île-de-France - Jouy-en-Josas-Antony More information on centre

Department of medicine and healthcare technologies (MTS) University Paris-Saclay-CEA-INRAE; Food Allergy Laboratory 91191 GIF SUR YVETTE Website

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