OPEN COMPETITIONS CR-2021-ALIMH-1

Junior Research Scientist on the protein-energy needs of humans

75005 PARIS

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INRAE presentation

The French National Research Institute for Agriculture, Food, and the Environment (INRAE) is a public research establishment under the dual authority of the Ministry of Agriculture and the Ministry of Research.

INRAE is recruiting researchers by open competition and offering permanent position.

It is a major player in research and innovation created on 1st of January 2020. INRAE is a research institute resulting from the merger of INRA and IRSTEA. It is a community of 12,000 people with more than 200 research units and 42 experimental units located throughout France.

The institute is among the world leaders in agricultural and food sciences, in plant and animal sciences, and is 11th in the world in ecology and environment. INRAE’s main goal is to be a key player in the transitions necessary to address major global challenges. In the face of the increase in population, climate change, scarcity of resources and decline in biodiversity, the institute develops solutions for multiperformance agriculture, high quality food and sustainable management of resources and ecosystems.

Work environment, missions and activities

The Nutritional Physiology and Eating Behaviour (PNCA) joint research unit is organized in four teams: 1. Protein intake and intestinal adaptations; 2. Protein intake and metabolic regulations; 3. Protein Intake, Nutritional Security and Cardiometabolic Risk; 4. Protein Intake and Neuroscience of eating behaviour. The PNCA has facilitated access to the Volunteer Research Centre at Avicenne Hospital. The PNCA has a "rodent" animal facility and several technical units (mass spectrometry, cellular and molecular biology, biochemistry) at AgroParisTech.
You will join team 2 managed by Dalila Azzout-Marniche and will work with members of the team and the unit on the strategic and priority theme of low protein content/quality diets.
The objective of the research will be to provide original data on conditions for maintaining energy homeostasis with insufficient protein intake or imbalanced amino acid profiles in relation to what can be observed in plant-predominant diets. To do this, preclinical studies in rodents and nutritional interventions in humans will be necessary varying the intake of protein and some amino acids. These interventions must realistically mimic the protein transition scenarios (more or less extensive revegetation of the diet) in different types of populations. To deepen the knowledge of these adaptive responses, you will explore the mechanisms responsible for metabolic orientations and the associated signalling pathways involving, in particular, hormones (insulin, leptin, ghrelin) and various growth factors involved in these processes (IGF1, FGF21…).
You will join the collaborative network of the team and the unit, giving you access to high throughput screening platforms (transcriptome, metabolome...) or within the framework of the Associated International Laboratory (LIA) between the PNCA unit and St John's Hospital (Bangalore, India).

Assignment to Saclay's site from the year 2022

Training and skills

PhD or equivalent

Candidates must have a PhD or equivalent.
Training in the fields of physiology and/or physiopathology is highly recommended and sound knowledge of nutritional physiology and metabolic regulations would be desirable. Good knowledge of approaches for studying metabolic signatures in connection with biological and behavioral phenotypes, experience in research and managing a research project, data processing and interpretation would also be highly desirable. Skills in indirect calorimetry would be appreciated.
Candidates should have a good command of English, and long-term international experience would also be desirable. Successful candidates who have not yet acquired this experience abroad will be required to do so after their probationary period (1st year).

INRAE's life quality

By joining our teams, you benefit from:

- 30 days of annual leave + 15 days "Reduction of Working Time" (for a full time);
- parenting support: CESU childcare, leisure services;
- skills development systems: training, career advise;
- social support: advice and listening, social assistance and loans;
- holiday and leisure services: holiday vouchers, accommodation at preferential rates;
sports and cultural activities;
- collective catering.

Offer reference

  • Profile number: CR-2021-ALIMH-1
  • Corps: CRCN
  • Category: A
  • Open competition number: 10

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